Bromomethylcyclopropane → N-(5-Cyclopropylmethoxymethyl-6-methyl-pyridin-2-yl)-2,2-dimethyl-propionamide

HRID 1454843Notes

Reaction equation

[OH:1][CH2:2][C:3]1[CH:4]=[CH:5][C:6]([NH:10][C:11](=[O:16])[C:12]([CH3:15])([CH3:14])[CH3:13])=[N:7][C:8]=1[CH3:9].Br[CH2:18][CH:19]1[CH2:21][CH2:20]1>>[CH:19]1([CH2:18][O:1][CH2:2][C:3]2[CH:4]=[CH:5][C:6]([NH:10][C:11](=[O:16])[C:12]([CH3:13])([CH3:15])[CH3:14])=[N:7][C:8]=2[CH3:9])[CH2:21][CH2:20]1

Participants

Reactant 2

HCID 81503Bromomethylcyclopropane

HCID 68844472N-(5-Hydroxymethyl-6-methyl-pyridin-2-yl)-2,2-dimethyl-propionamide

Product 1

HCID 68843080N-(5-Cyclopropylmethoxymethyl-6-methyl-pyridin-2-yl)-2,2-dimethyl-propionamide

Procedure

This material was prepared in analogy to example 86 step A] from N-(5-Hydroxymethyl-6-methyl-pyridin-2-yl)-2,2-dimethyl-propionamide (0.445 g) and bromomethyl cyclopropane (0.275 g) as a light yellow oil (0.357g). MS (ESI): 277.2 (MH+).

Sources & evidence

ORD record: ord-5a5919471ba3413c838921387a47bd9a
Source dataset: uspto-grants-2009_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07482341B2

Reaction notes

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