2,5-Difluorobenzenesulfonyl chloride → N-(5-Cyclopropylmethoxymethyl-6-methyl-pyridin-2-yl)-2,5-difluoro-benzenesulfonamide

HRID 1454846Notes

Reaction equation

HRID 1454846 reaction equation
[CH:1]1([CH2:4][O:5][CH2:6][C:7]2[CH:8]=[CH:9][C:10]([NH2:14])=[N:11][C:12]=2[CH3:13])[CH2:3][CH2:2]1.[F:15][C:16]1[CH:21]=[CH:20][C:19]([F:22])=[CH:18][C:17]=1[S:23](Cl)(=[O:25])=[O:24]>>[CH:1]1([CH2:4][O:5][CH2:6][C:7]2[CH:8]=[CH:9][C:10]([NH:14][S:23]([C:17]3[CH:18]=[C:19]([F:22])[CH:20]=[CH:21][C:16]=3[F:15])(=[O:25])=[O:24])=[N:11][C:12]=2[CH3:13])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 27369112,5-Difluorobenzenesulfonyl chlorideHCID 688431485-Cyclopropylmethoxymethyl-6-methyl-pyridin-2-ylamine

Product 1

HCID 68843870N-(5-Cyclopropylmethoxymethyl-6-methyl-pyridin-2-yl)-2,5-difluoro-benzenesulfonamide

Procedure

This material was prepared in analogy to example 1 from 5-cyclopropylmethoxymethyl-6-methyl-pyridin-2-ylamine (0.053 g) and 2,5-difluoro-benzenesulfonyl chloride (0.059 g) as a light yellow solid (0.063 g). MS (ESI−): 367.0 ([M−H]−)

Sources & evidence

ORD record
ord-fc221f7f30f246059ca3ce29b368c3ab
Source dataset
uspto-grants-2009_01
Patent number
US07482341B2

Reaction notes

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