5-Fluoro-2-methylbenzenesulphonyl chloride → N-(5-Cyclopropylmethoxymethyl-6-methyl-pyridin-2-yl)-5-fluoro-2-methyl-benzenesulfonamide

HRID 1454847Notes

Reaction equation

HRID 1454847 reaction equation
[CH:1]1([CH2:4][O:5][CH2:6][C:7]2[CH:8]=[CH:9][C:10]([NH2:14])=[N:11][C:12]=2[CH3:13])[CH2:3][CH2:2]1.[F:15][C:16]1[CH:17]=[CH:18][C:19]([CH3:26])=[C:20]([S:22](Cl)(=[O:24])=[O:23])[CH:21]=1>>[CH:1]1([CH2:4][O:5][CH2:6][C:7]2[CH:8]=[CH:9][C:10]([NH:14][S:22]([C:20]3[CH:21]=[C:16]([F:15])[CH:17]=[CH:18][C:19]=3[CH3:26])(=[O:23])=[O:24])=[N:11][C:12]=2[CH3:13])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 1362865-Fluoro-2-methylbenzenesulphonyl chlorideHCID 688431485-Cyclopropylmethoxymethyl-6-methyl-pyridin-2-ylamine

Product 1

HCID 68845292N-(5-Cyclopropylmethoxymethyl-6-methyl-pyridin-2-yl)-5-fluoro-2-methyl-benzenesulfonamide

Procedure

This material was prepared in analogy to example 1 from 5-cyclopropylmethoxymethyl-6-methyl-pyridin-2-ylamine (0.053 g) and 5-fluoro-2-methyl-benzenesulfonyl chloride (0.058 g) as a light yellow solid (0.063 g). MS (ESI−): 363.3 ([M−H]−)

Sources & evidence

ORD record
ord-f7377151274341ca8bc8ceb5d6213a39
Source dataset
uspto-grants-2009_01
Patent number
US07482341B2

Reaction notes

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