Iodoethane → N-(5-Ethoxymethyl-6-methyl-pyridin-2-yl)-2,2-dimethyl-propionamide

HRID 1454856Notes

Reaction equation

[OH:1][CH2:2][C:3]1[CH:4]=[CH:5][C:6]([NH:10][C:11](=[O:16])[C:12]([CH3:15])([CH3:14])[CH3:13])=[N:7][C:8]=1[CH3:9].I[CH2:18][CH3:19]>>[CH2:18]([O:1][CH2:2][C:3]1[CH:4]=[CH:5][C:6]([NH:10][C:11](=[O:16])[C:12]([CH3:13])([CH3:15])[CH3:14])=[N:7][C:8]=1[CH3:9])[CH3:19]

Participants

Reactant 2

HCID 6340Iodoethane

HCID 68844472N-(5-Hydroxymethyl-6-methyl-pyridin-2-yl)-2,2-dimethyl-propionamide2×

Product 1

HCID 68840796N-(5-Ethoxymethyl-6-methyl-pyridin-2-yl)-2,2-dimethyl-propionamide

Procedure

This material was prepared in analogy to example 86 step A] from N-(5-hydroxymethyl-6-methyl-pyridin-2-yl)-2,2-dimethyl-propionamide (0.445 g, product of example 112 step B]) and iodoethane (0.34 g) as a light yellow oil (0.32 g). MS (ESI): 251.2 (MH+).

Sources & evidence

ORD record: ord-31223a8a0c98409eaf2c72ff743f359c
Source dataset: uspto-grants-2009_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07482341B2

Reaction notes

Loading…