Sodium Hydroxide → 5-Ethoxymethyl-6-methyl-pyridin-2-ylamine

HRID 1454857Notes

Reaction equation

[CH2:1]([O:3][CH2:4][C:5]1[CH:6]=[CH:7][C:8]([NH:12]C(=O)C(C)(C)C)=[N:9][C:10]=1[CH3:11])[CH3:2].[OH-].[Na+]>>[CH2:1]([O:3][CH2:4][C:5]1[CH:6]=[CH:7][C:8]([NH2:12])=[N:9][C:10]=1[CH3:11])[CH3:2]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 68840796N-(5-Ethoxymethyl-6-methyl-pyridin-2-yl)-2,2-dimethyl-propionamide

Product 1

HCID 688408275-Ethoxymethyl-6-methyl-pyridin-2-ylamine

Procedure

This material was prepared in analogy to example 86 step B] from N-(5-ethoxymethyl-6-methyl-pyridin-2-yl)-2,2-dimethyl-propionamide (0.32 g) and 3M aqueous NaOH (2.62 mL) as a yellow oil (0.28 g) that was used directly in the next step.

Sources & evidence

ORD record: ord-260856e1cf7a460982668da25a610f54
Source dataset: uspto-grants-2009_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07482341B2

Reaction notes

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