3-(Trifluoromethyl)benzenesulfonyl chloride → N-(5-Cyclopropylmethoxymethyl-pyridin-2-yl)-3-trifluoromethyl-benzenesulfonamide

HRID 1454864Notes

Reaction equation

HRID 1454864 reaction equation
[CH:1]1([CH2:4][O:5][CH2:6][C:7]2[CH:8]=[CH:9][C:10]([NH2:13])=[N:11][CH:12]=2)[CH2:3][CH2:2]1.[F:14][C:15]([F:27])([F:26])[C:16]1[CH:17]=[C:18]([S:22](Cl)(=[O:24])=[O:23])[CH:19]=[CH:20][CH:21]=1>>[CH:1]1([CH2:4][O:5][CH2:6][C:7]2[CH:8]=[CH:9][C:10]([NH:13][S:22]([C:18]3[CH:19]=[CH:20][CH:21]=[C:16]([C:15]([F:14])([F:26])[F:27])[CH:17]=3)(=[O:24])=[O:23])=[N:11][CH:12]=2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 27332503-(Trifluoromethyl)benzenesulfonyl chlorideHCID 621942995-Cyclopropylmethoxymethyl-pyridin-2-ylamine

Product 1

HCID 68845578N-(5-Cyclopropylmethoxymethyl-pyridin-2-yl)-3-trifluoromethyl-benzenesulfonamide

Procedure

This material was prepared in analogy to example 1 from 5-cyclopropylmethoxymethyl-pyridin-2-ylamine (0.051 g) and 3-(trifluromethyl)-benzenesulfonyl chloride (0.077 g) as a crystalline white solid (0.062 g). MS (ESI−): 385.0 ([M−H]−)

Sources & evidence

ORD record
ord-8bb9be0363f74f3c98ff25d72a193e28
Source dataset
uspto-grants-2009_01
Patent number
US07482341B2

Reaction notes

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