2-Fluoroethyl bromide → N-[5-(2-Fluoro-ethoxymethyl)-6-methyl-pyridin-2-yl]-2,2-dimethyl-propionamide

HRID 1454870Notes

Reaction equation

HRID 1454870 reaction equation
[OH:1][CH2:2][C:3]1[CH:4]=[CH:5][C:6]([NH:10][C:11](=[O:16])[C:12]([CH3:15])([CH3:14])[CH3:13])=[N:7][C:8]=1[CH3:9].Br[CH2:18][CH2:19][F:20]>>[F:20][CH2:19][CH2:18][O:1][CH2:2][C:3]1[CH:4]=[CH:5][C:6]([NH:10][C:11](=[O:16])[C:12]([CH3:13])([CH3:15])[CH3:14])=[N:7][C:8]=1[CH3:9]

Participants

3

Reactant 2

HCID 129822-Fluoroethyl bromideHCID 68844472N-(5-Hydroxymethyl-6-methyl-pyridin-2-yl)-2,2-dimethyl-propionamide2×

Product 1

HCID 86604238N-[5-(2-Fluoro-ethoxymethyl)-6-methyl-pyridin-2-yl]-2,2-dimethyl-propionamide

Procedure

This material was prepared in analogy to example 86 step A] from N-(5-hydroxymethyl-6-methyl-pyridin-2-yl)-2,2-dimethyl-propionamide (0.556 g, product of example 112 step B]) and 1-bromo-2-fluoro-ethane (0.475 g) as a light yellow gum (0.115 g). MS (ESI): 269.3 (MH+).

Sources & evidence

ORD record
ord-2a76463275cd47b4ab049ec8f2aa6112
Source dataset
uspto-grants-2009_01
Patent number
US07482341B2

Reaction notes

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