4-Chlorotoluene-2-sulphonyl chloride → 3-Chloro-N-(5-cyclopropylmethoxymethyl-6-methyl-pyridin-2-yl)-benzenesulfonamide

HRID 1454875Notes

Reaction equation

HRID 1454875 reaction equation
[CH:1]1([CH2:4][O:5][CH2:6][C:7]2[CH:8]=[CH:9][C:10]([NH2:14])=[N:11][C:12]=2[CH3:13])[CH2:3][CH2:2]1.[Cl:15][C:16]1[CH:17]=[C:18]([S:23](Cl)(=[O:25])=[O:24])[C:19](C)=[CH:20][CH:21]=1>>[Cl:15][C:16]1[CH:17]=[C:18]([S:23]([NH:14][C:10]2[CH:9]=[CH:8][C:7]([CH2:6][O:5][CH2:4][CH:1]3[CH2:3][CH2:2]3)=[C:12]([CH3:13])[N:11]=2)(=[O:25])=[O:24])[CH:19]=[CH:20][CH:21]=1

Participants

3

Reactant 2

HCID 1004154-Chlorotoluene-2-sulphonyl chlorideHCID 688431485-Cyclopropylmethoxymethyl-6-methyl-pyridin-2-ylamine

Product 1

HCID 688454073-Chloro-N-(5-cyclopropylmethoxymethyl-6-methyl-pyridin-2-yl)-benzenesulfonamide

Procedure

This material was prepared in analogy to example 1 from 5-cyclopropylmethoxymethyl-6-methyl-pyridin-2-ylamine (0.06 g) and 3-chloro-6-methyl-benzenesulfonyl chloride (0.072 g) as a light yellow solid (0.07 g). MS (ESI−): 364.9 ([M−H] )

Sources & evidence

ORD record
ord-69a002eec6eb43dc98307967bd4656e6
Source dataset
uspto-grants-2009_01
Patent number
US07482341B2

Reaction notes

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