2,4-Dichloro-6-methylbenzenesulfonyl chloride → 2,4-Dichloro-N-(5-cyclopropylmethoxymethyl-6-methyl-pyridin-2-yl)-6-methyl-benzenesulfonamide

HRID 1454876Notes

Reaction equation

HRID 1454876 reaction equation
[CH:1]1([CH2:4][O:5][CH2:6][C:7]2[CH:8]=[CH:9][C:10]([NH2:14])=[N:11][C:12]=2[CH3:13])[CH2:3][CH2:2]1.[Cl:15][C:16]1[CH:21]=[C:20]([Cl:22])[CH:19]=[C:18]([CH3:23])[C:17]=1[S:24](Cl)(=[O:26])=[O:25]>>[Cl:15][C:16]1[CH:21]=[C:20]([Cl:22])[CH:19]=[C:18]([CH3:23])[C:17]=1[S:24]([NH:14][C:10]1[CH:9]=[CH:8][C:7]([CH2:6][O:5][CH2:4][CH:1]2[CH2:3][CH2:2]2)=[C:12]([CH3:13])[N:11]=1)(=[O:26])=[O:25]

Participants

3

Reactant 2

HCID 28013872,4-Dichloro-6-methylbenzenesulfonyl chlorideHCID 688431485-Cyclopropylmethoxymethyl-6-methyl-pyridin-2-ylamine

Product 1

HCID 688429352,4-Dichloro-N-(5-cyclopropylmethoxymethyl-6-methyl-pyridin-2-yl)-6-methyl-benzenesulfonamide

Procedure

This material was prepared in analogy to example 1 from 5-cyclopropylmethoxymethyl-6-methyl-pyridin-2-ylamine (0.06 g) and 2,4-dichloro-6-methyl-benzenesulfonyl chloride (0.089 g) as an amorphous light yellow solid (0.058 g). MS (ESI−): 413.1 ([M−H]−)

Sources & evidence

ORD record
ord-439b194095df42b196f6c3554bd664f8
Source dataset
uspto-grants-2009_01
Patent number
US07482341B2

Reaction notes

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