2,4-Dichloro-6-methylbenzenesulfonyl chloride → 2,4-Dichloro-N-[6-(3-fluoro-benzyloxymethyl)-pyridin-2-yl]-6-methyl-benzenesulfonamide
Reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:15]=[CH:16][CH:17]=1)[CH2:5][O:6][CH2:7][C:8]1[N:13]=[C:12]([NH2:14])[CH:11]=[CH:10][CH:9]=1.[Cl:18][C:19]1[CH:24]=[C:23]([Cl:25])[CH:22]=[C:21]([CH3:26])[C:20]=1[S:27](Cl)(=[O:29])=[O:28]>>[Cl:18][C:19]1[CH:24]=[C:23]([Cl:25])[CH:22]=[C:21]([CH3:26])[C:20]=1[S:27]([NH:14][C:12]1[CH:11]=[CH:10][CH:9]=[C:8]([CH2:7][O:6][CH2:5][C:4]2[CH:15]=[CH:16][CH:17]=[C:2]([F:1])[CH:3]=2)[N:13]=1)(=[O:29])=[O:28]Participants
3
Procedure
This material was prepared in analogy to example 1 from 6-(3-fluoro-benzyloxymethyl)-pyridin-2-ylamine (0.06 g) and 2,4-dichloro-6methyl-benzenesulfonyl chloride (0.074 g) as a yellow solid (0.12 g). MS (ESI−): 453.1 ([M−H]−).
Sources & evidence
- ORD record
- ord-01c932ca51a44c4bbe917c8a24b0e415
- Source dataset
- uspto-grants-2009_01
- Patent number
- US07482341B2
Reaction notes
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