Sodium Hydroxide → 2-Pyridinamine, 6-[(3,3,3-trifluoropropoxy)methyl]-

HRID 1454888Notes

Reaction equation

HRID 1454888 reaction equation
CC(C)(C)C([NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH2:12][O:13][CH2:14][CH2:15][C:16]([F:19])([F:18])[F:17])[N:7]=1)=O.[OH-].[Na+]>>[F:19][C:16]([F:17])([F:18])[CH2:15][CH2:14][O:13][CH2:12][C:8]1[N:7]=[C:6]([NH2:5])[CH:11]=[CH:10][CH:9]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 68842009HCID 68842009, compound

Product 1

HCID 688426152-Pyridinamine, 6-[(3,3,3-trifluoropropoxy)methyl]-

Procedure

This material was prepared in analogy to example 86 step B] from 2,2-dimethyl-N-[6-(3,3,3-trifluoro-propoxymethyl)-pyridin-2-yl]-propionamide (0.2 g) and 3M aqueous NaOH (1.31 mL) as a brown oil (0.159 g). MS (ESI): 221.2 (MH+).

Sources & evidence

ORD record
ord-8d37ae79b3ea4dfda75b8804b4af02cf
Source dataset
uspto-grants-2009_01
Patent number
US07482341B2

Reaction notes

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