Sodium Hydroxide → 6-(2-Cyclopropyl-ethoxymethyl)-pyridin-2-ylamine

HRID 1454894Notes

Reaction equation

HRID 1454894 reaction equation
[CH:1]1([CH2:4][CH2:5][O:6][CH2:7][C:8]2[N:13]=[C:12]([NH:14]C(=O)C(C)(C)C)[CH:11]=[CH:10][CH:9]=2)[CH2:3][CH2:2]1.[OH-].[Na+]>>[CH:1]1([CH2:4][CH2:5][O:6][CH2:7][C:8]2[N:13]=[C:12]([NH2:14])[CH:11]=[CH:10][CH:9]=2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 68842043N-[6-(2-cyclopropyl-ethoxymethyl)-pyridin-2-yl]-2,2-dimethyl-propionamide

Product 1

HCID 688421766-(2-Cyclopropyl-ethoxymethyl)-pyridin-2-ylamine

Procedure

This material was prepared in analogy to example 86 step B] from N-[6-(2-cyclopropyl-ethoxymethyl)-pyridin-2-yl]-2,2-dimethyl-propionamide (0.51 g) and 3M aqueous NaOH (3.7 mL) as a light yellow oil (0.39 g) that was used directly in the next step.

Sources & evidence

ORD record
ord-cfb8d46292dc43bfaad594fb05232523
Source dataset
uspto-grants-2009_01
Patent number
US07482341B2

Reaction notes

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