3-Chlorobenzenesulphonyl chloride → 3-Chloro-N-[6-(2-cyclopropyl-ethoxymethyl)-pyridin-2-yl]-benzenesulfonamide

HRID 1454895Notes

Reaction equation

HRID 1454895 reaction equation
[CH:1]1([CH2:4][CH2:5][O:6][CH2:7][C:8]2[N:13]=[C:12]([NH2:14])[CH:11]=[CH:10][CH:9]=2)[CH2:3][CH2:2]1.[Cl:15][C:16]1[CH:17]=[C:18]([S:22](Cl)(=[O:24])=[O:23])[CH:19]=[CH:20][CH:21]=1>>[Cl:15][C:16]1[CH:17]=[C:18]([S:22]([NH:14][C:12]2[CH:11]=[CH:10][CH:9]=[C:8]([CH2:7][O:6][CH2:5][CH2:4][CH:1]3[CH2:3][CH2:2]3)[N:13]=2)(=[O:24])=[O:23])[CH:19]=[CH:20][CH:21]=1

Participants

3

Reactant 2

HCID 179093-Chlorobenzenesulphonyl chlorideHCID 688421766-(2-Cyclopropyl-ethoxymethyl)-pyridin-2-ylamine

Product 1

HCID 688429643-Chloro-N-[6-(2-cyclopropyl-ethoxymethyl)-pyridin-2-yl]-benzenesulfonamide

Procedure

This material was prepared in analogy to example 1 from 6-(2-cyclopropyl-ethoxymethyl)-pyridin-2-ylamine (0.08 g) and 3-chloro-benzenesulfonyl chloride (0.095 g) as a light yellow gum (0.096 g). MS (ESI−): 365.0 ([M−H]−).

Sources & evidence

ORD record
ord-9a37aeeb21f5453496572a723155bffe
Source dataset
uspto-grants-2009_01
Patent number
US07482341B2

Reaction notes

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