4-Fluoro-3-(trifluoromethyl)benzenesulfonyl Chloride → n-[6-(2-Cyclopropyl-ethoxymethyl)-pyridin-2-yl]-4-fluoro-3-trifluoromethyl-benzenesulfonamide

HRID 1454897Notes

Reaction equation

HRID 1454897 reaction equation
[CH:1]1([CH2:4][CH2:5][O:6][CH2:7][C:8]2[N:13]=[C:12]([NH2:14])[CH:11]=[CH:10][CH:9]=2)[CH2:3][CH2:2]1.[F:15][C:16]1[CH:21]=[CH:20][C:19]([S:22](Cl)(=[O:24])=[O:23])=[CH:18][C:17]=1[C:26]([F:29])([F:28])[F:27]>>[CH:1]1([CH2:4][CH2:5][O:6][CH2:7][C:8]2[N:13]=[C:12]([NH:14][S:22]([C:19]3[CH:20]=[CH:21][C:16]([F:15])=[C:17]([C:26]([F:29])([F:27])[F:28])[CH:18]=3)(=[O:24])=[O:23])[CH:11]=[CH:10][CH:9]=2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 27375494-Fluoro-3-(trifluoromethyl)benzenesulfonyl ChlorideHCID 688421766-(2-Cyclopropyl-ethoxymethyl)-pyridin-2-ylamine

Product 1

HCID 68841680n-[6-(2-Cyclopropyl-ethoxymethyl)-pyridin-2-yl]-4-fluoro-3-trifluoromethyl-benzenesulfonamide

Procedure

This material was prepared in analogy to example 1 from 6-(2-cyclopropyl-ethoxymethyl)-pyridin-2-ylamine (0.08 g) and 4-fluoro-3-(trifluormethyl)-benzenesulfonyl chloride (0.12 g) as a light yellow gum (0.08 g). MS (ESI−): 417.0 ([M−H]−).

Sources & evidence

ORD record
ord-0f4ffbb83dc44a8e910cd1be0b18d3e3
Source dataset
uspto-grants-2009_01
Patent number
US07482341B2

Reaction notes

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