3-Chloro-2-methylbenzenesulfonyl chloride → HCID 68842087, compound

HRID 1454917Notes

Reaction equation

HRID 1454917 reaction equation
[O:1]([C:8]1[CH:9]=[CH:10][C:11]([NH2:14])=[N:12][CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:15][C:16]1[C:17]([CH3:26])=[C:18]([S:22](Cl)(=[O:24])=[O:23])[CH:19]=[CH:20][CH:21]=1>N1C=CC=CC=1>[Cl:15][C:16]1[C:17]([CH3:26])=[C:18]([S:22]([NH:14][C:11]2[CH:10]=[CH:9][C:8]([O:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)=[CH:13][N:12]=2)(=[O:24])=[O:23])[CH:19]=[CH:20][CH:21]=1

Participants

4

Reactant 2

HCID 5227343-Chloro-2-methylbenzenesulfonyl chlorideHCID 221794545-Phenoxypyridin-2-amine

Product 1

HCID 68842087HCID 68842087, compoundYield 18.4%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

5-Phenoxy-pyridin-2-ylamine (100 mg) was treated with 3-chloro-2-methylbenzenesulfonyl chloride (122 mg) in the presence of pyridine (3 mL) as described in example 172, step C] to give 3-Chloro-2-methyl-N-(5-phenoxy-pyridin-2-yl)-benzenesulfonamide (37 mg) as a white foam. MS (ESI): 375.1 (MH+).

Sources & evidence

ORD record
ord-8433362758354f2dae96de221fa80453
Source dataset
uspto-grants-2009_01
Patent number
US07482341B2

Reaction notes

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