HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(6-Chloropyridazin-3-yl)-1-(2,6-difluorophenyl)but-3-yn-2-one → 2-chloro-5-(2,6-difluorophenyl)-6H-pyrido[1,2-b]pyridazin-6-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(6-Chloropyridazin-3-yl)-1-(2,6-difluorophenyl)but-3-yn-2-one | HCID 57531233 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 2-chloro-5-(2,6-difluorophenyl)-6H-pyrido[1,2-b]pyridazin-6-one | HCID 57531226 | — |
Reaction Steps
A solution of 1-(6-chloropyridazin-3-yl)-1-(2,6-difluorophenyl)but-3-yn-2-one (10.2 g) in toluene was heated to 90° C. for 3 hours. LCMS analysis revealed the reaction was complete and the reaction was concentrated to yield a solid. The crude material was purified via silica gel chromatography (CH2Cl2/EtOAc/MeOH) to yield the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07482345B2 |
| Source dataset | uspto-grants-2009_01 |
| ORD ID | ord-9593ed235d824eb68bbf47529d79f111 |
| Source note | uspto-grants-2009_01 |