Ammonium Hydroxide → 2-amino-5-(2,6-difluorophenyl)-6H-pyrido[1,2-b]pyridazin-6-one

Participants

Role	Name	HCID	Charge
Reactant	Ammonium Hydroxide	HCID 14923	—
Reactant	Ammonium Chloride	HCID 25517	—
Reactant	2-chloro-5-(2,6-difluorophenyl)-6H-pyrido[1,2-b]pyridazin-6-one	HCID 57531226	—
Solvent	Water	HCID 962	—
Product	2-amino-5-(2,6-difluorophenyl)-6H-pyrido[1,2-b]pyridazin-6-one	HCID 57531236	—

Reaction Conditions

Temperature	90 °C

Reaction Steps

To 2-chloro-5-(2,6-difluorophenyl)-6H-pyrido[1,2-b]pyridazin-6-one (1.1 g, 3.77 mmol) was added NH4Cl (100 mL) and NH4OH (100 mL). The resulting solution was heated to 90° C. and stirred for 16 hrs until complete. The reaction was cooled to ambient temperature and diluted with H2O (500 mL) until a precipitate formed. The solid precipitate was collected and dried to yield the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07482345B2
Source dataset	uspto-grants-2009_01
ORD ID	ord-08ee52dc7da84685874ac0be4d7a3057
Source note	uspto-grants-2009_01