HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(5-Bromopyridin-2-yl)-1-(2,6-difluorophenyl)but-3-yn-2-one → 7-bromo-1-(2,6-difluorophenyl)-2H-quinolizin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(5-Bromopyridin-2-yl)-1-(2,6-difluorophenyl)but-3-yn-2-one | HCID 57531243 | — |
| Solvent | N,N,N',N'-Tetramethylethylenediamine | HCID 8037 | — |
| Product | 7-bromo-1-(2,6-difluorophenyl)-2H-quinolizin-2-one | HCID 57531230 | — |
Reaction Steps
To a solution of 1-(5-bromopyridin-2-yl)-1-(2,6-difluorophenyl)but-3-yn-2-one (2 g) in TMEDA was heated to 90° C. for 1 h. LCMS analysis revealed the reaction was complete and the reaction was concentrated. The crude material was purified by silica gel chromatography (CH2Cl2/acetone) to yield the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07482345B2 |
| Source dataset | uspto-grants-2009_01 |
| ORD ID | ord-8d9dfddc5c6b42f5ba3a68dc4f89ac36 |
| Source note | uspto-grants-2009_01 |