HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1454981Generated: October 31, 2026
Triethylamine → 1-(2,6-difluorophenyl)-7-[(2,4-difluorophenyl)ethynyl]-2H-quinolizin-2-one
https://huagongshe.com/reaction/1454981
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1-Ethynyl-2,4-difluorobenzene | HCID 5063820 | — |
| Reactant | 7-bromo-1-(2,6-difluorophenyl)-2H-quinolizin-2-one | HCID 57531230 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Catalyst | HCID 178418476 | HCID 178418476 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 1-(2,6-difluorophenyl)-7-[(2,4-difluorophenyl)ethynyl]-2H-quinolizin-2-one | HCID 16749634 | — |
Reaction Steps
To a solution of 7-bromo-1-(2,6-difluorophenyl)-2H-quinolizin-2-one (100 mg) was added 1ethynyl-2,4-difluorobenzene (82 mg), triethylamine (0.17 ml), dichlorobis(triphenylphosphine)palladium (25 mg), CuI (6 mg) in DMF was heated to 100° C. until reaction complete. The mixture was diluted with ethyl acetate, washed with water (4×), brine, dried over MgSO4, and concentrated to yield crude material. The crude material was purified by silica gel chromatography (100% ethyl acetate) to yield the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07482345B2 |
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| Source dataset | uspto-grants-2009_01 |
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| ORD ID | ord-f3750d6a8b094c95ac2f642c92f69bfd |
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| Source note | uspto-grants-2009_01 |
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