反应详情

A solution of 1-(2,6-difluorophenyl)-7-[(2,4-difluorophenyl)ethynyl]-2H-quinolizin-2-one in methanol was added a catalytic amount of Lindlar catalyst under hydrogen atmosphere (1 atm) for 1 hour. The mixture was filtered through celite and the filtrate was concentrated. The crude material was purified by silica gel (100% ethyl acetate) to give the title compound.

1. filtrationThe mixture was filtered through celite
2. concentrationthe filtrate was concentrated
3. customThe crude material was purified by silica gel (100% ethyl acetate)