HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2,6-difluorophenyl)-7-[(2,4-difluorophenyl)ethynyl]-2H-quinolizin-2-one → HCID 68997044, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2,6-difluorophenyl)-7-[(2,4-difluorophenyl)ethynyl]-2H-quinolizin-2-one | HCID 16749634 | — |
| Catalyst | Lindlars catalyst | HCID 131709914 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 68997044 | HCID 68997044 | — |
Reaction Steps
A solution of 1-(2,6-difluorophenyl)-7-[(2,4-difluorophenyl)ethynyl]-2H-quinolizin-2-one in methanol was added a catalytic amount of Lindlar catalyst under hydrogen atmosphere (1 atm) for 1 hour. The mixture was filtered through celite and the filtrate was concentrated. The crude material was purified by silica gel (100% ethyl acetate) to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07482345B2 |
| Source dataset | uspto-grants-2009_01 |
| ORD ID | ord-4945e0596a6a4f668652a3924f01cfbc |
| Source note | uspto-grants-2009_01 |