Selectfluor → HCID 178461800, compound

HRID 1455002Notes

Reaction equation

HRID 1455002 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:19]=[CH:20][CH:21]=1)[CH2:5][S:6][C:7]1[N:12]=[C:11]([OH:13])[CH:10]=[C:9]([NH:14][C@H:15]([CH3:18])[CH2:16][OH:17])[N:8]=1.[B-](F)(F)(F)[F:23].[B-](F)(F)(F)F.C1[N+]2(CCl)CC[N+](F)(CC2)C1>CO>[Cl:1][C:2]1[CH:3]=[C:4]([CH:19]=[CH:20][CH:21]=1)[CH2:5][S:6][C:7]1[N:12]=[C:11]([OH:13])[C:10]([F:23])=[C:9]([NH:14][C@H:15]([CH3:18])[CH2:16][OH:17])[N:8]=1

Participants

4

Reactant 2

HCID 2724933SelectfluorHCID 178461795HCID 178461795, compound

Product 1

HCID 178461800HCID 178461800, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The product of Example 3 (0.1 g) was dissolved in methanol (10 ml), Selectfluor™ (0.12 g) added and stirred for 20 h. The mixture was evaporated and purified by silica gel chromatography (5% methanol/DCM) to yield the title product as a white solid. Yield 19 mg.

Workup

  1. customThe mixture was evaporated
  2. custompurified by silica gel chromatography (5% methanol/DCM)

Sources & evidence

ORD record
ord-4f821785523a439abb537ba1059fa179
Source dataset
uspto-grants-2009_01
Patent number
US07482355B2

Reaction notes

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