Sodium Hydroxide → HCID 68919233, compound

HRID 1455279Notes

Reaction equation

HRID 1455279 reaction equation
[OH-:1].[Na+].[CH2:3]([C:5]1[C:9]([O:10][C:11]2[CH:18]=[C:17](C)[C:14]([C:15]#[N:16])=[C:13](C)[CH:12]=2)=[C:8]([CH2:21][CH3:22])[N:7]([CH2:23][CH2:24][O:25]C)[N:6]=1)[CH3:4]>CO>[C:15]([C:14]1[CH:13]=[CH:12][C:11]([O:10][C:9]2[C:5]([CH2:3][CH3:4])=[N:6][N:7]([CH2:23][C:24]([OH:25])=[O:1])[C:8]=2[CH2:21][CH3:22])=[CH:18][CH:17]=1)#[N:16]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 68912995HCID 68912995, compound

Product 1

HCID 68919233HCID 68919233, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2M Sodium hydroxide (2 ml) was added to a solution of the ester of Example 34 (800 mg, 2.46 mmol), in methanol (10 ml), and the reaction mixture was then stirred at room temperature for 2 hours. The reaction mixture was evaporated and water (20 ml) was added. The aqueous solution was acidified with 2M hydrochloric acid, until pH 2 was reached. A precipitate formed and this was collected by filtration, washed with water (2×5 ml) and dried, to provide the title compound (701 mg, 95%) as a white solid.

Workup

  1. customThe reaction mixture was evaporated
  2. additionwater (20 ml) was added
  3. customA precipitate formed
  4. filtrationthis was collected by filtration
  5. washwashed with water (2×5 ml)
  6. customdried

Sources & evidence

ORD record
ord-7a660ccb1233403fbd3bce32181fc2c3
Source dataset
uspto-grants-2009_01
Patent number
US07482375B2

Reaction notes

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