Sodium Hydroxide → HCID 68919233, compound

Participants

Reaction Steps

2M Sodium hydroxide (2 ml) was added to a solution of the ester of Example 34 (800 mg, 2.46 mmol), in methanol (10 ml), and the reaction mixture was then stirred at room temperature for 2 hours. The reaction mixture was evaporated and water (20 ml) was added. The aqueous solution was acidified with 2M hydrochloric acid, until pH 2 was reached. A precipitate formed and this was collected by filtration, washed with water (2×5 ml) and dried, to provide the title compound (701 mg, 95%) as a white solid.

Provenance & Evidence