HCID 11455930, compound → Caprazene

HRID 1455482Notes

Reaction equation

HRID 1455482 reaction equation
[CH3:1][N:2]1[C@@H:9]([C@H:10]([O:26][C@@H:27]2[O:31][C@H:30]([CH2:32][NH2:33])[C@@H:29]([OH:34])[C@H:28]2[OH:35])[C@H:11]2[O:15][C@@H:14]([N:16]3[C:22](=[O:23])[NH:21][C:19](=[O:20])[CH:18]=[CH:17]3)[C@H:13]([OH:24])[C@@H:12]2[OH:25])[C:7](=[O:8])[N:6]([CH3:36])[C@H:5]([C:37]([OH:39])=[O:38])[C@@H:4](O)[CH2:3]1>Cl>[CH3:1][N:2]1[C@@H:9]([CH:10]([O:26][C@@H:27]2[O:31][C@H:30]([CH2:32][NH2:33])[C@@H:29]([OH:34])[C@H:28]2[OH:35])[C@H:11]2[O:15][C@@H:14]([N:16]3[C:22](=[O:23])[NH:21][C:19](=[O:20])[CH:18]=[CH:17]3)[C@H:13]([OH:24])[C@@H:12]2[OH:25])[C:7](=[O:8])[N:6]([CH3:36])[C:5]([C:37]([OH:39])=[O:38])=[CH:4][CH2:3]1

Participants

3

Reactant 1

HCID 11455930HCID 11455930, compound

Product 1

HCID 68249819CaprazeneYield 20%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

An amount of caprazol was dissolved in an amount of iN aqueous hydrochloric acid and the resultant solution was heated at 100° C. for 3 hours, thereby to produce caprazene in the yield of 20%. About 20% of caprazol was left unreacted. Respective chemical structure of each compound was confirmed by NMR analysis. The resulting reaction solution was concentrated under a reduced pressure and the resulting residue was subjected to a silica-gel column chromatography. Thus, there can be separated caprazene and caprazol, from each other.

Sources & evidence

ORD record
ord-305c7d414ed64dbb8aeef86bc1c06d05
Source dataset
uspto-grants-2009_01
Patent number
US07482439B2

Reaction notes

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