HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1455490Generated: October 31, 2026
Methyl iodide → 1-Bromo-2,4-difluoro-3-methoxybenzene
https://huagongshe.com/reaction/1455490
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-Bromo-2,6-difluorophenol | HCID 18371110 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 1-Bromo-2,4-difluoro-3-methoxybenzene | HCID 18371109 | — |
Reaction Steps
A quantity of 3.7 g of 3-hydroxy-2,4-difluoro-bromobenzene is dissolved in 25 ml of acetone and 2.5 g of potassium carbonate is added followed by 2.2 ml of methyl iodide. The mixture is stirred at 20° C. for 6 hours and the solvent evaporated. After addition of dichloromethane, the suspension is filtered. Evaporation of the solvent affords the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07482454B2 |
|---|
| Source dataset | uspto-grants-2009_01 |
|---|
| ORD ID | ord-b843a672c08d4b78bed914dc9bbe8fc3 |
|---|
| Source note | uspto-grants-2009_01 |
|---|
