Methyl iodide → 1-Bromo-2,4-difluoro-3-methoxybenzene

HRID 1455490Notes

Reaction equation

HRID 1455490 reaction equation
[OH:1][C:2]1[C:3]([F:10])=[C:4]([Br:9])[CH:5]=[CH:6][C:7]=1[F:8].[C:11](=O)([O-])[O-].[K+].[K+].CI>CC(C)=O>[CH3:11][O:1][C:2]1[C:3]([F:10])=[C:4]([Br:9])[CH:5]=[CH:6][C:7]=1[F:8]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 183711103-Bromo-2,6-difluorophenol

Product 1

HCID 183711091-Bromo-2,4-difluoro-3-methoxybenzene

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Conditions

Temperature
20 °C

Procedure

A quantity of 3.7 g of 3-hydroxy-2,4-difluoro-bromobenzene is dissolved in 25 ml of acetone and 2.5 g of potassium carbonate is added followed by 2.2 ml of methyl iodide. The mixture is stirred at 20° C. for 6 hours and the solvent evaporated. After addition of dichloromethane, the suspension is filtered. Evaporation of the solvent affords the desired product.

Workup

  1. customthe solvent evaporated
  2. additionAfter addition of dichloromethane
  3. filtrationthe suspension is filtered
  4. customEvaporation of the solvent

Sources & evidence

ORD record
ord-b843a672c08d4b78bed914dc9bbe8fc3
Source dataset
uspto-grants-2009_01
Patent number
US07482454B2

Reaction notes

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