反应详情

3-Methyloxy-2-phenylquinoline-4-carboxylic acid (200 mg, 0.72 mmol) [J. Med. Chem. 1999, 42, 1053-1065] was suspended in CH2Cl2 (5 mL) at 0° C. and oxalyl chloride (62 μL, 0.72 mmol) was added with stirring. After stirring at 0° C. for 1 h the cooling bath was removed and the solution allowed to stir at room temperature for 18 h. After this time the solvent was evaporated and the crude acid chloride used in the subsequent reaction without further purification.

1. stirringAfter stirring at 0° C. for 1 h the cooling bath
2. customwas removed
3. stirringto stir at room temperature for 18 h
4. customAfter this time the solvent was evaporated
5. customthe crude acid chloride used in the subsequent reaction without further purification