Hydrazine → HCID 178480239, compound

HRID 1455539Notes

Reaction equation

HRID 1455539 reaction equation
F[C:2]1[CH:16]=[CH:15][C:14]([I:17])=[CH:13][C:3]=1[C:4]([CH:6]1[CH2:11][CH2:10][N:9]([CH3:12])[CH2:8][CH2:7]1)=O.[NH2:18][NH2:19]>CS(C)=O>[I:17][C:14]1[CH:13]=[C:3]2[C:2](=[CH:16][CH:15]=1)[NH:19][N:18]=[C:4]2[CH:6]1[CH2:11][CH2:10][N:9]([CH3:12])[CH2:8][CH2:7]1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 57535470HCID 57535470, compound

Product 1

HCID 178480239HCID 178480239, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of 4-(2-fluoro-5-iodobenzoyl)-1-methylpiperidine (4.20 g, 12.1 mmol), anhydrous NH2NH2 (30 mL), and DMSO (15 mL) was heated at 100° C. overnight, diluted with ice water and filtered. The filtercake was washed with water and dried in vacuo to provide the title compound (4.1 g, 99%), characterized by HNMR and mass spectral analyses.

Workup

  1. filtrationfiltered
  2. washThe filtercake was washed with water
  3. customdried in vacuo

Sources & evidence

ORD record
ord-e960675e2f064c62bb1416663de01f5e
Source dataset
uspto-grants-2009_01
Patent number
US07482461B2

Reaction notes

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