Hydrochloric Acid → Hydrochloric Acid

HRID 1455543Notes

Reaction equation

HRID 1455543 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([C:14]([NH:16][S:17]([C:20]2[CH:25]=[C:24]([C:26]([F:29])([F:28])[F:27])[CH:23]=[C:22]([C:30]([F:33])([F:32])[F:31])[CH:21]=2)(=[O:19])=[O:18])=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:34]>CO.C(Cl)Cl.CCOCC>[NH:8]1[CH2:13][CH2:12][CH:11]([C:14]([NH:16][S:17]([C:20]2[CH:21]=[C:22]([C:30]([F:31])([F:32])[F:33])[CH:23]=[C:24]([C:26]([F:29])([F:27])[F:28])[CH:25]=2)(=[O:18])=[O:19])=[O:15])[CH2:10][CH2:9]1.[ClH:34]

Participants

7

Reactant 2

HCID 313Hydrochloric AcidHCID 44389185HCID 44389185, compound

Product 2

HCID 313Hydrochloric AcidHCID 86597095HCID 86597095, compound

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

2 g of 4-(3,5-bis-trifluoromethyl-benzenesulfonylaminocarbonyl)-piperidine-1-carboxylic acid tert.-butyl ester are dissolved in a mixture of 1 ml MeOH and 9 ml of CH2Cl2. The resulting mixture is treated at RT with 20 ml of 3 N HCl in (C2H5)2O for ca. 16 hours. Solvent is evaporated and N-(piperidine-4-carbonyl)-3,5-bis-trifluoromethyl-benzenesulfonamide in the form of a hydrochloride is obtained. m.p. 285-291°.

Workup

  1. customSolvent is evaporated

Sources & evidence

ORD record
ord-f8727a9cc7284f6bad86bb83bd31b887
Source dataset
uspto-grants-2009_01
Patent number
US07482462B2

Reaction notes

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