Triethylamine → HCID 57429716, compound

HRID 1455565Notes

Reaction equation

HRID 1455565 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11]([CH2:15][S:16](=[O:32])(=[O:31])[NH:17]C(C2C=CC=CC=2)C2C=CC=CC=2)([OH:14])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].C(N(CC)CC)C>CO.[Pd]>[C:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][C:11]([OH:14])([CH2:15][S:16](=[O:32])(=[O:31])[NH2:17])[CH2:12][CH2:13]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

5

Reactant 2

HCID 8471TriethylamineHCID 68443033HCID 68443033, compound

Product 1

HCID 57429716HCID 57429716, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

5.19 g of 4-[(benzhydryl-sulfamoyl)-methyl]-4-hydroxy-piperidine-1-carboxylic acid tert.-butyl ester in 150 ml of MeOH are treated with 100 μl of triethylamine and the mixture obtained is hydrogenated overnight at RT with 10% Pd/C as a catalyst. From the mixture obtained the catalyst is filtrated off, solvent is evaporated and the evaporation residue is subjected to chromatography on silica gel. 4-Hydroxy-4-sulfamoylmethyl-piperidine-1-carboxylic acid tert.-butyl ester are obtained. m.p. 176-180°.

Workup

  1. customthe mixture obtained
  2. customFrom the mixture obtained the catalyst
  3. filtrationis filtrated off
  4. customsolvent is evaporated

Sources & evidence

ORD record
ord-bc12100e760341ac8492f2675a1f4cc8
Source dataset
uspto-grants-2009_01
Patent number
US07482462B2

Reaction notes

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