Hydrochloric Acid → HCID 68822206, compound

Participants

Reaction Steps

A solution of {(S)-1-[(5-Cyclopropyl-1,2,4-oxadiazol-3-yl)-hydroxy-methyl]-propyl}-carbamic acid tert-butyl ester (3.41 g, 0.011 mmol) in 4N HCl in dioxane (43 mL, 0.172 mmol) is stirred at room temperature for 2 h. Solvent evaporated under reduced pressure. Residue triturated with a mixture of ethyl acetate and ether. It is then filtered to give (S)-2-Amino-1-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)-butan-1-ol HCl salt as a solid (2.47 g).

Provenance & Evidence