Hydrochloric Acid → HCID 68822206, compound

HRID 1455593Notes

Reaction equation

HRID 1455593 reaction equation
C(OC(=O)[NH:7][C@H:8]([CH:11]([C:13]1[N:17]=[C:16]([CH:18]2[CH2:20][CH2:19]2)[O:15][N:14]=1)[OH:12])[CH2:9][CH3:10])(C)(C)C.O1CCOCC1.[ClH:28]>>[ClH:28].[NH2:7][CH:8]([CH2:9][CH3:10])[C@@H:11]([C:13]1[N:17]=[C:16]([CH:18]2[CH2:20][CH2:19]2)[O:15][N:14]=1)[OH:12]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 57535333HCID 57535333, compound

Product 1

HCID 68822206HCID 68822206, compound

Procedure

A solution of {(S)-1-[(5-Cyclopropyl-1,2,4-oxadiazol-3-yl)-hydroxy-methyl]-propyl}-carbamic acid tert-butyl ester (3.41 g, 0.011 mmol) in 4N HCl in dioxane (43 mL, 0.172 mmol) is stirred at room temperature for 2 h. Solvent evaporated under reduced pressure. Residue triturated with a mixture of ethyl acetate and ether. It is then filtered to give (S)-2-Amino-1-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)-butan-1-ol HCl salt as a solid (2.47 g).

Workup

  1. customSolvent evaporated under reduced pressure
  2. customResidue triturated with a mixture of ethyl acetate and ether
  3. filtrationIt is then filtered

Sources & evidence

ORD record
ord-66dc58ec9fba4e5796618947303385b8
Source dataset
uspto-grants-2009_01
Patent number
US07482448B2

Reaction notes

Loading…