Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | 5-Bromonicotinonitrile | HCID 736793 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 453565-56-5 | HCID 73739646 | — |
Reaction Steps
A mixture of 3-bromo-5-cyanopyridine (1.0 eq), hydroxylamine hydrochloride (1.5 eq.), K2CO3 (2.1 eq) in ethanol (0.1 M) was stirred at 80° C. for 3 days. The mixture was concentrated, diluted with EtOAc and aqueous NaHCO3. The title compound was isolated by filtration as beige solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07482456B2 |
|---|
| Source dataset | uspto-grants-2009_01 |
|---|
| ORD ID | ord-cca6fc708da04e2b98c662d6b99c1044 |
|---|
| Source note | uspto-grants-2009_01 |
|---|
