Potassium Carbonate → 453565-56-5

HRID 1455634Notes

Reaction equation

HRID 1455634 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([C:8]#[N:9])[CH:7]=1.Cl.[NH2:11][OH:12].C([O-])([O-])=O.[K+].[K+]>C(O)C>[Br:1][C:2]1[CH:7]=[C:6]([C:8](=[N:11][OH:12])[NH2:9])[CH:5]=[N:4][CH:3]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 443297Hydroxyamine hydrochlorideHCID 7367935-Bromonicotinonitrile

Product 1

HCID 73739646453565-56-5

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

A mixture of 3-bromo-5-cyanopyridine (1.0 eq), hydroxylamine hydrochloride (1.5 eq.), K2CO3 (2.1 eq) in ethanol (0.1 M) was stirred at 80° C. for 3 days. The mixture was concentrated, diluted with EtOAc and aqueous NaHCO3. The title compound was isolated by filtration as beige solid.

Workup

  1. concentrationThe mixture was concentrated
  2. additiondiluted with EtOAc and aqueous NaHCO3

Sources & evidence

ORD record
ord-cca6fc708da04e2b98c662d6b99c1044
Source dataset
uspto-grants-2009_01
Patent number
US07482456B2

Reaction notes

Loading…