Bromine → HCID 178434719, compound

HRID 1455639Notes

Reaction equation

HRID 1455639 reaction equation
[CH3:1][C:2]1[N:6]=[C:5]([C:7]2[C:8]([OH:13])=[N:9][CH:10]=[CH:11][CH:12]=2)[O:4][N:3]=1.[Br:14]Br>CC(O)=O>[Br:14][C:11]1[CH:12]=[C:7]([C:5]2[O:4][N:3]=[C:2]([CH3:1])[N:6]=2)[C:8]([OH:13])=[N:9][CH:10]=1

Participants

4

Reactant 2

HCID 24408BromineHCID 178434729HCID 178434729, compound

Product 1

HCID 178434719HCID 178434719, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution 3-(3-methyl-1,2,4-oxadiazol-5-yl)pyridin-2-ol in AcOH (0.2M) and bromine (1.2 eq) was stirred 18 h at 20° C. and then concentrated. The residue was co-evaporated with benzene (2×) and used as such in the next step.

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-9cefcca1589d4fd697cb14e0d74e8f2b
Source dataset
uspto-grants-2009_01
Patent number
US07482456B2

Reaction notes

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