HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Dimethoxyethane → Methyl 6-amino-4'-(methylthio)-1,1'-biphenyl-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Dimethoxyethane | HCID 8071 | — |
| Reactant | Cesium fluoride | HCID 25953 | — |
| Reactant | 4-(Methylthio)phenylboronic acid | HCID 2733959 | — |
| Reactant | Methyl 4-amino-3-iodobenzoate | HCID 4104649 | — |
| Solvent | Hexane | HCID 8058 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Methyl 6-amino-4'-(methylthio)-1,1'-biphenyl-3-carboxylate | HCID 68952232 | — |
Reaction Steps
Prepared according to the general procedure Coupling-1 (CsF, DME, 20° C.) using [4-(methylthio)phenyl]boronic acid and methyl 4-amino-3-iodo-benzoate as starting material. Flash chromatography (Hexane:EtOAc, 70:30) afforded the title compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07482456B2 |
| Source dataset | uspto-grants-2009_01 |
| ORD ID | ord-0adf13041db245d89b9598d772143801 |
| Source note | uspto-grants-2009_01 |