Water → Ethyl 3-(3-hexanoyl-4-methoxyphenyl)propanoate

Participants

Reaction Conditions

Reaction Steps

98 ml (0.7 mol) of hexanoyl chloride are added dropwise to a solution of 70 g (0.336 mol) of ethyl3-(4-methoxyphenyl)propanoate in 280 ml of dichloromethane. 89 g (0.67 mol) of aluminium chloride are then added in small amounts, and the mixture is heated for one hour at 50° C. The mixture is poured into cold water and extracted with ether. The organic phase is washed with sodium bicarbonate solution. After drying (Na2SO4) and evaporating off the solvents, a yellow liquid is obtained, and then distilled: Bp0.4 mmHg=160° C. (74 g; 72%);

Provenance & Evidence