Water → Ethyl 3-(3-hexanoyl-4-methoxyphenyl)propanoate

HRID 1455691노트

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HRID 1455691 반응식
[C:1](Cl)(=[O:7])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].[CH2:9]([O:11][C:12](=[O:23])[CH2:13][CH2:14][C:15]1[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=1)[CH3:10].[Cl-].[Al+3].[Cl-].[Cl-].O>ClCCl>[CH2:9]([O:11][C:12](=[O:23])[CH2:13][CH2:14][C:15]1[CH:16]=[CH:17][C:18]([O:21][CH3:22])=[C:19]([C:1](=[O:7])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6])[CH:20]=1)[CH3:10]

참가 물질

6

반응물 4

HCID 962WaterHCID 67340Hexanoyl chlorideHCID 348843Ethyl 3-(4-methoxyphenyl)propanoateHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 69051926Ethyl 3-(3-hexanoyl-4-methoxyphenyl)propanoate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

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온도
50 °C

실험 절차

98 ml (0.7 mol) of hexanoyl chloride are added dropwise to a solution of 70 g (0.336 mol) of ethyl3-(4-methoxyphenyl)propanoate in 280 ml of dichloromethane. 89 g (0.67 mol) of aluminium chloride are then added in small amounts, and the mixture is heated for one hour at 50° C. The mixture is poured into cold water and extracted with ether. The organic phase is washed with sodium bicarbonate solution. After drying (Na2SO4) and evaporating off the solvents, a yellow liquid is obtained, and then distilled: Bp0.4 mmHg=160° C. (74 g; 72%);

후처리

  1. extractionextracted with ether
  2. washThe organic phase is washed with sodium bicarbonate solution
  3. dry with materialAfter drying (Na2SO4)
  4. customevaporating off the solvents
  5. customa yellow liquid is obtained
  6. distillationdistilled
  7. customBp0.4 mmHg=160° C. (74 g; 72%)

출처 및 근거

ORD 기록
ord-0acad4d685f04d45bc5a8edde034adec
출처 데이터셋
uspto-grants-2009_01
특허 번호
US07482484B2

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