反应详情

温度

50 °C

98 ml (0.7 mol) of hexanoyl chloride are added dropwise to a solution of 70 g (0.336 mol) of ethyl3-(4-methoxyphenyl)propanoate in 280 ml of dichloromethane. 89 g (0.67 mol) of aluminium chloride are then added in small amounts, and the mixture is heated for one hour at 50° C. The mixture is poured into cold water and extracted with ether. The organic phase is washed with sodium bicarbonate solution. After drying (Na2SO4) and evaporating off the solvents, a yellow liquid is obtained, and then distilled: Bp0.4 mmHg=160° C. (74 g; 72%);

1. extractionextracted with ether
2. washThe organic phase is washed with sodium bicarbonate solution
3. dry with materialAfter drying (Na2SO4)
4. customevaporating off the solvents
5. customa yellow liquid is obtained
6. distillationdistilled
7. customBp0.4 mmHg=160° C. (74 g; 72%)