Toluene → HCID 9991546, compound

HRID 1455694Notes

Reaction equation

HRID 1455694 reaction equation
[CH2:1]([C:7]1[CH:8]=[C:9]2[C:13](=[CH:14][C:15]=1[O:16]C)[C:12](=[O:18])[CH2:11][CH2:10]2)[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].[Cl-].[Al+3].[Cl-].[Cl-].C1(C)C=CC=CC=1>O>[CH2:1]([C:7]1[CH:8]=[C:9]2[C:13](=[CH:14][C:15]=1[OH:16])[C:12](=[O:18])[CH2:11][CH2:10]2)[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6]

Participants

5

Reactant 3

HCID 1140TolueneHCID 6451240Aluminum(III) ChlorideHCID 12144845HCID 12144845, compound

Product 1

HCID 9991546HCID 9991546, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

5.6 g (22.7 mmol) of 5-hexyl-6-methoxyindan-1-one, 9.4 g of aluminium chloride and 125 ml of toluene are refluxed for 15 minutes. The mixture is poured into water and extracted with ether. The organic phase is dried (Na2SO4) and the solvents are evaporated off. The residue is purified by flash chromatography (4.5 g; 85%).

Workup

  1. extractionextracted with ether
  2. dry with materialThe organic phase is dried (Na2SO4)
  3. customthe solvents are evaporated off
  4. customThe residue is purified by flash chromatography (4.5 g; 85%)

Sources & evidence

ORD record
ord-2002783d70f54fcf8b8cee99f7fa332c
Source dataset
uspto-grants-2009_01
Patent number
US07482484B2

Reaction notes

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