Water → HCID 11858598, compound

HRID 1455695Notes

Reaction equation

HRID 1455695 reaction equation
[CH2:1]([O:3][C:4](=[O:9])[CH2:5][CH2:6][CH2:7]Br)[CH3:2].[O-]CC.[Na+].[CH2:14]([C:20]1[CH:21]=[C:22]2[C:26](=[CH:27][C:28]=1[OH:29])[C:25](=[O:30])[CH2:24][CH2:23]2)[CH2:15][CH2:16][CH2:17][CH2:18][CH3:19].O>C(O)C>[CH2:1]([O:3][C:4](=[O:9])[CH2:5][CH2:6][CH2:7][O:29][C:28]1[CH:27]=[C:26]2[C:22](=[CH:21][C:20]=1[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19])[CH2:23][CH2:24][C:25]2=[O:30])[CH3:2]

Participants

6

Reactant 4

HCID 962WaterHCID 76300Ethyl 4-bromobutyrateHCID 2723922Sodium ethoxideHCID 9991546HCID 9991546, compound

Product 1

HCID 11858598HCID 11858598, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

3.6 ml of ethyl4-bromobutyrate dissolved in 15 ml of ethanol are added to a mixture of sodium ethoxide (1.6 g, 0.0233 mol) and 5-hexyl-6-hydroxyindan-1-one (4.5 g, 0.0194 mol) in 45 ml of ethanol. The reaction medium is heated for 5 hours at reflux. The mixture is poured into water and extracted with ether. The organic phase is dried (Na2SO4) and the solvents are evaporated off (5.9 g; 60%).

Workup

  1. temperatureThe reaction medium is heated for 5 hours
  2. temperatureat reflux
  3. extractionextracted with ether
  4. dry with materialThe organic phase is dried (Na2SO4)
  5. customthe solvents are evaporated off (5.9 g; 60%)

Sources & evidence

ORD record
ord-01aeb0da9e824689a3ff9269caa4c9c1
Source dataset
uspto-grants-2009_01
Patent number
US07482484B2

Reaction notes

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