Toluene → HCID 9992783, compound

HRID 1455700Notes

Reaction equation

HRID 1455700 reaction equation
[CH2:1]([C:7]1[CH:8]=[C:9]2[C:13](=[CH:14][C:15]=1[O:16]C)[C:12](=[O:18])[C:11]([CH3:20])([CH3:19])[CH2:10]2)[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].[Cl-].[Al+3].[Cl-].[Cl-].C1(C)C=CC=CC=1>O>[CH2:1]([C:7]1[CH:8]=[C:9]2[C:13](=[CH:14][C:15]=1[OH:16])[C:12](=[O:18])[C:11]([CH3:19])([CH3:20])[CH2:10]2)[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6]

Participants

5

Reactant 3

HCID 1140TolueneHCID 6451240Aluminum(III) ChlorideHCID 10423493HCID 10423493, compound

Product 1

HCID 9992783HCID 9992783, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

1.93 g (7 mmol) of 5-hexyl-6-methoxy-2,2-dimethylindan-1-one, 2.84 g (21 mmol) of aluminium chloride and 40 ml of toluene are heated for 15 minutes at reflux. The mixture is poured into water and extracted with ether. The organic phase is dried (Na2SO4) and the solvent evaporated off. The residue is purified by flash chromatography (dichloromethane, 2.8 g; 90%).

Workup

  1. temperatureat reflux
  2. extractionextracted with ether
  3. dry with materialThe organic phase is dried (Na2SO4)
  4. customthe solvent evaporated off
  5. customThe residue is purified by flash chromatography (dichloromethane, 2.8 g; 90%)

Sources & evidence

ORD record
ord-894103825a6c4380be4d9a8b386e4cee
Source dataset
uspto-grants-2009_01
Patent number
US07482484B2

Reaction notes

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