Hydroxyamine hydrochloride → HCID 85435445, compound

HRID 1455702Notes

Reaction equation

HRID 1455702 reaction equation
[CH2:1]([C:7]1[CH:15]=[C:14]2[C:10]([C:11](=O)[CH2:12][CH2:13]2)=[CH:9][C:8]=1[O:17][CH2:18][CH2:19][CH2:20][C:21]([OH:23])=[O:22])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].Cl.[NH2:25][OH:26].C([O-])(=O)C.[Na+]>C(O)C>[CH2:1]([C:7]1[CH:15]=[C:14]2[C:10]([C:11](=[N:25][OH:26])[CH2:12][CH2:13]2)=[CH:9][C:8]=1[O:17][CH2:18][CH2:19][CH2:20][C:21]([OH:23])=[O:22])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6]

Participants

5

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 10087256HCID 10087256, compound

Product 1

HCID 85435445HCID 85435445, compoundYield 50.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 50 mg (0.157 mmol) of 4-(6-hexyl-3-oxo-5-indanyloxy)butyric acid, 13 mg (0.188 mmol) of hydroxylamine hydrochloride and 32 mg (0.393 mmol) of sodium acetate in 3 ml of 85% ethanol is heated at reflux for 1 hour. After cooling, the mixture is poured into 50 ml of ice-cold water. The solid formed is isolated by filtration, washed with water and dried to give 26.3 mg (50%) of the expected product.

Workup

  1. temperatureis heated
  2. temperatureat reflux for 1 hour
  3. temperatureAfter cooling
  4. customThe solid formed
  5. customis isolated by filtration
  6. washwashed with water
  7. customdried

Sources & evidence

ORD record
ord-4108f316714c4c98b3ec70c367f8c7a1
Source dataset
uspto-grants-2009_01
Patent number
US07482484B2

Reaction notes

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