Cesium carbonate → HCID 69048264, compound

HRID 1455704Notes

Reaction equation

HRID 1455704 reaction equation
[OH:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][CH2:7][C:8]2=[O:11])=[CH:4][C:3]=1[I:12].C(=O)([O-])[O-].[Cs+].[Cs+].[CH2:19]([O:21][C:22](=[O:27])[CH2:23][CH2:24][CH2:25]Br)[CH3:20]>CC(C)=O>[CH2:19]([O:21][C:22](=[O:27])[CH2:23][CH2:24][CH2:25][O:1][C:2]1[CH:10]=[C:9]2[C:5](=[CH:4][C:3]=1[I:12])[CH2:6][CH2:7][C:8]2=[O:11])[CH3:20]

Participants

5

Reactant 3

HCID 10796Cesium carbonateHCID 76300Ethyl 4-bromobutyrateHCID 57458786HCID 57458786, compound

Product 1

HCID 69048264HCID 69048264, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A mixture of 6-hydroxy-5-iodoindan-1-one (6.36 g, 23.2 mmol), caesium carbonate (15.12 g, 46.4 mmol) and ethyl4-bromobutyrate (9.05 g, 46.4 mmol) in acetone (60 ml) is heated at reflux pendant 1 hour 15 minutes.

Workup

  1. temperatureis heated
  2. temperatureat reflux pendant 1 hour 15 minutes

Sources & evidence

ORD record
ord-6cd6824f3b3942fda4aa50f2cd5c7928
Source dataset
uspto-grants-2009_01
Patent number
US07482484B2

Reaction notes

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