Water → 5-Bromo-6-methoxy-1-indanone

HRID 1455711노트

반응식

HRID 1455711 반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH2:10][CH2:11][C:12](Cl)=[O:13])[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].[Cl-].[Al+3].[Cl-].[Cl-].O>ClCCl>[Br:1][C:2]1[CH:3]=[C:4]2[C:5](=[CH:6][C:7]=1[O:8][CH3:9])[C:12](=[O:13])[CH2:11][CH2:10]2

참가 물질

5

반응물 3

HCID 962WaterHCID 6451240Aluminum(III) ChlorideHCID 866051613-(3-Bromo-4-methoxyphenyl)propanoyl chloride

생성물 1

HCID 222787185-Bromo-6-methoxy-1-indanone

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

48 g (0.18 mol) of 3-(3-bromo-4-methoxyphenyl)propanoyl chloride are dissolved in 500 ml of dichloromethane. 72 g (0.54 mol) of aluminium chloride are added in small amounts. The reaction medium is stirred for 2 hours and then poured into water and the phases are separated by settling. The organic phase is dried (Na2SO4) and the solvent is evaporated off: (39.8 g). The product is triturated in ethanol, filtered off and dried (25 g; 63%)

후처리

  1. customthe phases are separated
  2. dry with materialThe organic phase is dried (Na2SO4)
  3. customthe solvent is evaporated off
  4. customThe product is triturated in ethanol
  5. filtrationfiltered off
  6. customdried (25 g; 63%)

출처 및 근거

ORD 기록
ord-ea2641d28fe64319bf67cfb74ba6b068
출처 데이터셋
uspto-grants-2009_01
특허 번호
US07482484B2

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