Water → 5-bromo-6-hydroxy-2,3-dihydro-1H-inden-1-one

HRID 1455712Notes

Reaction equation

HRID 1455712 reaction equation
[Cl-].[Al+3].[Cl-].[Cl-].[Br:5][C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][C:14]=1[O:15]C)[C:11](=[O:17])[CH2:10][CH2:9]2.O>C1(C)C=CC=CC=1>[Br:5][C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][C:14]=1[OH:15])[C:11](=[O:17])[CH2:10][CH2:9]2

Participants

5

Reactant 3

HCID 962WaterHCID 6451240Aluminum(III) ChlorideHCID 222787185-Bromo-6-methoxy-1-indanone

Product 1

HCID 103313075-bromo-6-hydroxy-2,3-dihydro-1H-inden-1-one

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

46.7 g (0.35 mol) of aluminium chloride are added portionwise to a solution of 28.3 g (0.117 mol) of 5-bromo-6-methoxyindan-1-one in 500 ml of toluene. The reaction mixture is heated at reflux for 15 minutes and is then poured into water and the phases are separated by settling (sparingly soluble product).

Workup

  1. temperatureThe reaction mixture is heated
  2. temperatureat reflux for 15 minutes
  3. customthe phases are separated

Sources & evidence

ORD record
ord-76ee50a658ee47a7a3901261ed4e9db3
Source dataset
uspto-grants-2009_01
Patent number
US07482484B2

Reaction notes

Loading…