HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 5-bromo-6-hydroxy-2,3-dihydro-1H-inden-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Reactant | 5-Bromo-6-methoxy-1-indanone | HCID 22278718 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 5-bromo-6-hydroxy-2,3-dihydro-1H-inden-1-one | HCID 10331307 | — |
Reaction Steps
46.7 g (0.35 mol) of aluminium chloride are added portionwise to a solution of 28.3 g (0.117 mol) of 5-bromo-6-methoxyindan-1-one in 500 ml of toluene. The reaction mixture is heated at reflux for 15 minutes and is then poured into water and the phases are separated by settling (sparingly soluble product).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07482484B2 |
| Source dataset | uspto-grants-2009_01 |
| ORD ID | ord-76ee50a658ee47a7a3901261ed4e9db3 |
| Source note | uspto-grants-2009_01 |