Methanol → HCID 23078179, compound

HRID 1455780Notes

Reaction equation

HRID 1455780 reaction equation
CO.C(OC([NH:10][CH:11]([CH2:14][CH2:15][CH2:16][C:17]1[CH:22]=[CH:21][C:20]([S:23][C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([C:30]([F:33])([F:32])[F:31])[CH:25]=2)=[CH:19][C:18]=1[Cl:34])[CH2:12][OH:13])=O)(C)(C)C>C(OCC)(=O)C>[ClH:34].[NH2:10][CH:11]([CH2:14][CH2:15][CH2:16][C:17]1[CH:22]=[CH:21][C:20]([S:23][C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([C:30]([F:33])([F:31])[F:32])[CH:25]=2)=[CH:19][C:18]=1[Cl:34])[CH2:12][OH:13]

Participants

4

Reactant 2

HCID 887MethanolHCID 23078141HCID 23078141, compound

Product 1

HCID 23078179HCID 23078179, compoundYield 187.3%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a methanol solution (5 mL) of the compound of Example 39 (0.27 g), ethyl acetate containing 3 mol/L hydrochloric acid (5 mL) was added and the mixture was stirred in an ice bath. The mixture was allowed to warm to room temperature and was left overnight. Subsequently, the solvent was removed under reduced pressure to give the desired product as a colorless powder (0.22 g).

Workup

  1. customSubsequently, the solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-226e9446d526420b839170ff99e19aba
Source dataset
uspto-grants-2009_01
Patent number
US07482491B2

Reaction notes

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