Formic Acid → HCID 53896014, compound

HRID 1455876Notes

Reaction equation

HRID 1455876 reaction equation
[CH3:1][C@@:2]12[C:10](=[O:11])[CH2:9][CH2:8][C@H:7]1[C@@H:6]1[CH2:12][CH:13]=[C:14]3[CH2:19][C@@H:18]([OH:20])[CH2:17][CH2:16][C@:15]3([CH3:21])[C@H:5]1[CH2:4][CH2:3]2.O.[CH:23](O)=[O:24]>>[CH:23]([O:20][C@H:18]1[CH2:17][CH2:16][C@@:15]2([CH3:21])[C:14](=[CH:13][CH2:12][C@@H:6]3[C@@H:5]2[CH2:4][CH2:3][C@@:2]2([CH3:1])[C@H:7]3[CH2:8][CH2:9][C:10]2=[O:11])[CH2:19]1)=[O:24]

Participants

4

Reactant 3

HCID 284Formic AcidHCID 962WaterHCID 5881Dehydroepiandrosterone

Product 1

HCID 53896014HCID 53896014, compound

Conditions

Temperature
60 °C

Procedure

Following the procedure described by Ringold (H. J. Ringold, et al., J. Am. Chem. Soc. 78, 816, 1956), dehydroepiandrosterone (2.88 g, 10 mmol) dissolved in 85% formic acid (100 mL) is heated at 60° C. for 1 h. After cooling, the mixture is poured into iced water and after 16 h, crystals are filtered and dried in vacuo.

Workup

  1. temperatureAfter cooling
  2. filtrationcrystals are filtered
  3. customdried in vacuo

Sources & evidence

ORD record
ord-a107ddf09ac14b8981d1d8f9172c521a
Source dataset
uspto-grants-1998_12
Patent number
US05843932

Reaction notes

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