Diethyl Ether → HCID 22105525, compound

HRID 1455939Notes

Reaction equation

HRID 1455939 reaction equation
C([O:5][C:6](=[O:32])[C:7]1[CH:12]=[CH:11][C:10]([N:13]([CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[O:23][CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[CH2:14][CH3:15])=[CH:9][C:8]=1[F:31])(C)(C)C.C(OCC)C>C(O)=O>[CH2:24]([O:23][C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=1[CH2:16][N:13]([C:10]1[CH:11]=[CH:12][C:7]([C:6]([OH:32])=[O:5])=[C:8]([F:31])[CH:9]=1)[CH2:14][CH3:15])[C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1

Participants

4

Reactant 2

HCID 3283Diethyl EtherHCID 22105534HCID 22105534, compound

Product 1

HCID 22105525HCID 22105525, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

tert-Butyl-4-[N-(2-benzyloxybenzyl)-N-ethylamino]-2-fluorobenzoate (1.81 g) in formic acid (5 mL) was heated on a steam bath until a clear solution was obtained. The reaction mixture was evaporated to dryness and the oil obtained solidified on trituration with diethyl ether to give 4-[N-(2-benzyloxybenzyl)-N-ethylamino]-2-fluorobenzoic acid, yield 0.51 g, mp 154° C.

Workup

  1. customwas obtained
  2. customThe reaction mixture was evaporated to dryness
  3. customthe oil obtained

Sources & evidence

ORD record
ord-de040ebd30ee4c518ef49d859a1180c0
Source dataset
uspto-grants-1998_12
Patent number
US05843942

Reaction notes

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